|The Tree of Life|
|Based on rRNA Sequencing by Carl Woese
1928-2012; see Nature, 2013, 493, 610
Office Hours: all day, every day, no appointment needed
|Basic Course Information|
|Course Syllabus||Journal Resources||Ideas for Papers|
|Our Discussion Center at Nature's Scitable Web Site
The first time you go to the site you will need to ask permission to use it.
And here are the course materials:
|What the Small Molecules Look Like|
|Topic 1 - Nucleic Acids|
|Structure of DNA and RNA
Watson and Crick
|The Code: Transcription and Translation||Complications:
Introns, Exons, Transposons
What is a Gene?
|Ancient DNA: Cave Men, Wooly Mammoths||Mitochondrial and Y Chromosomal DNA||Manipulating Genes
|Problem Set||Good and Poor Answers||Several of the animations are from the DNA Learning Center, operated by the Cold Spring Harbor Laboratory.
Find them also on YouTube
|Topic 2 - Protein Basics|
|Basics of Structure||Folding Proteins|
|Conformational Changes||Pores and Channels||Predicting Protein Structure and Function|
|Topic 3 - Enzyme Reaction Mechanisms|
|What Do Enzymes Do?||Chorismate Mutase||Squalene Cyclase|
|The Proteases||How to Eat Wood|
|Database of Protease Enzymes||Problem Set|
|Topic 4 - Biosynthetic Pathways:|
|The Shikimate Pathway||Squalene and Sterols||Databases of Biosynthetic Pathways|
|Molecular Evolution||Possible Problem Set|
|Tutorial: Sequence Alignment||Working with Graphics Files||Jmol/Rasmol Tutorial
(Link to Command summary)
|Short Tutorial: Swiss PDB Viewer|
|Useful Web Sites|
|Some of the pages on this site have embedded molecular structures that require Java for proper viewing and manipulation.
If you are using a Mac, you already have Java. PC users can download Java, FREE, from this site. Once you have installed it, it will be available automatically when it is needed.
|The Adobe Shockwave Flash Player also is used on some pages.|
Again, Mac users probably already have this installed, but may wish to upgrade to a newer version. PC users can download it for FREE by taking the link.