Here are some ideas for your papers. I would prefer you to come up with your own idea, but if you get stuck, any of these ideas would be OK. Your paper should not be based on just a single reference; those cited are to get you started! Search for more.
| Topic | Lead Reference | What's Cool |
|---|---|---|
| Aldolase-catalyzed condensations | Wong et al., Science , 2001, 294, 369 | The aldolase active site can accomodate multiple substrates |
| Parallel b-helices in proteins | Berger et al., Proc. Natl. Acad. Sci., 2001, 98, 14819 | The motif is much more common in surface proteins of disease organisms than in non-pathogenic microbes |
| Bacterial chaperones | Galan and Stebbins, Nature, 2001, 414, 77 | Bacterial chaperones keep proteins unfolded to ease injection into cells |
| "Mad Neanderthal" Disease | Med. Hypotheses, 2008, 71, 4; Science, 2003, 300, 227 | Did prion diseases kill off the Neanderthals? |
| NMR structure of an enzyme catalytic site | Kern et al., Science, 2002, 295, 1520 | Movements of the enzyme backbone during catalysis are detected |
| Family Tree of Bears | Proc. Natnl. Acad. Sci., 2008, 105, 17447; BMC Evol. Biol., 2008, 8, 220 | Analyses of the mitochondrial DNA of extinct bears |
| How amino acids form in space | Bernstein, Nature, 2002, 416, 401, 403 | These amino acids may be older than the solar system |
| Where did we come from? | Sykes, The Seven Daughters of Eve, Norton, 2001 | We are all descended from one woman who lived 130,000 years ago; discuss the scientific evidence |
| Y-chromsomal Adam? | Proc. Nat. Acad. Sci., 1996, 93, 196; Nature Genetics, 2000, 26, 388; Mol. Biol. Evol., 2001, 18, 1189 | Are men necessary? |
| DNA Repair | Chem. Rev., 2003, 103, 2729 | Is removal of damaged bases SN1 or SN2? |
| Designing Protein-Protein Interactions | Science, 2008, 319, 206 | Making proteins hang out together |
| How RNA folds | Curr. Opin. Struct. Biol., 2003, 13, 309 | What is the mechanistic relationship between folding and sequence? |
Here are a couple of examples of good papers from a few years ago:
| First Example | Second Example |