Ideas for Papers

Here are some ideas for your papers. I would prefer you to come up with your own idea, but if you get stuck, any of these ideas would be OK. Your paper should not be based on just a single reference; those cited are to get you started! Search for more.

Topic Lead Reference What's Cool
Aldolase-catalyzed condensations Wong et al., Science , 2001, 294, 369 The aldolase active site can accomodate multiple substrates
Parallel b-helices in proteins Berger et al., Proc. Natl. Acad. Sci., 2001, 98, 14819 The motif is much more common in surface proteins of disease organisms than in non-pathogenic microbes
Bacterial chaperones Galan and Stebbins, Nature, 2001, 414, 77 Bacterial chaperones keep proteins unfolded to ease injection into cells
"Mad Neanderthal" Disease Med. Hypotheses, 2008, 71, 4; Science, 2003, 300, 227 Did prion diseases kill off the Neanderthals?
NMR structure of an enzyme catalytic site Kern et al., Science, 2002, 295, 1520 Movements of the enzyme backbone during catalysis are detected
Family Tree of Bears Proc. Natnl. Acad. Sci., 2008, 105, 17447; BMC Evol. Biol., 2008, 8, 220 Analyses of the mitochondrial DNA of extinct bears
How amino acids form in space Bernstein, Nature, 2002, 416, 401, 403 These amino acids may be older than the solar system
Where did we come from? Sykes, The Seven Daughters of Eve, Norton, 2001 We are all descended from one woman who lived 130,000 years ago; discuss the scientific evidence
Y-chromsomal Adam? Proc. Nat. Acad. Sci., 1996, 93, 196; Nature Genetics, 2000, 26, 388; Mol. Biol. Evol., 2001, 18, 1189 Are men necessary?
DNA Repair Chem. Rev., 2003, 103, 2729 Is removal of damaged bases SN1 or SN2?
Designing Protein-Protein Interactions Science, 2008, 319, 206 Making proteins hang out together
How RNA folds Curr. Opin. Struct. Biol., 2003, 13, 309 What is the mechanistic relationship between folding and sequence?

Here are a couple of examples of good papers from a few years ago:

First Example Second Example


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